Spec: 2.0%-99.0% Chlorogenic Acid by HPLC

General Information

EINECS：206-325-6
CAS No.：327-97-9

Molecular formula：C16H18O9

Molecular weight：354.31

Physical property
Its hemihydrate is a needle like crystal (water) and it turns into anhydrous compound at 110 ℃;  the melting point is 208 ℃;the solubility in water at 25 is 4%, and the solubility in hot water is even higher; easily soluble in alcohol and acetone, very slightly soluble in ethyl acetate, and soluble in chloroform, ether, benzene, and other lipophilic organic solvent.

Botanic Source

Chlorogenic acid is a commonly used plant extract mainly from Lonicera japonica Thumb., Lonicera hypoglauca Miq., Lonicera confusa DC, the dried buds, flowers or leaves of lonicera dasytyla Rehd., the leaves of Eucommia ulmoides Oliv., the fruit of Crataegus oxyacantha Linn., as well as the seeds of Coffea arabica L., Coffea canephora Pierreex Froehn., and Coffea liberica Bu1.ex H1en..

Pharmacological Activity

1.  Anti-bacteria, Anti-inflammation and Anti-virus.

2.  Anti-oxidation

3.  Scavenging free radicals, Anti-aging, Anti-aging changes in the musculoskeletal system

4.  Inhibiting tumor and mutation

5.  Cardiovascular protection

6.  Blood pressure reduction

Applications

    1.  Food Industry

-Natural chlorogenic acid can be used to produce health foods and beverages; this healthy pharmaceutical raw material can benefit gallbladder, resist bacteria and virus, stop bleeding, increase white blood cells, shorten the time of blood clotting and bleeding, excite the physiological function of the central nervous system.

- Chlorogenic acid is an excellent food additive that can enhance the aroma and protect the color of food and beverages. A small amount of chlorogenic acid can help stabilize the pigment.

-As a natural preservative agent, chlorogenic acid can be used to increase the stability of food and beverage and keep them fresh.

-Chlorogenic acid is a natural antioxidant that can perfectly take the place of synthetic antioxidant.

     2. Healthcare industry

According to the pharmacopeia, chlorogenic acid is a common herbal extract with the functions of detoxification, anti- bacteria and anti-inflammation. Currently, it has become an important item for the quality control index of pharmaceutical preparations.

Healthcare products containing chlorogenic acid are endowed with the functions of clearing heat and detoxicating, skin rejuvenating and moisturizing, dispelling the excessive nicotine and alcohol, and so on.

3.  Cosmetic industry

As a natural plant extract, chlorogenic acid and other natural polyphenols can not only excellently protect collagen against the damage of reactive oxygen and other free radicals. But also effectively prevent human skin from the harmful effects resulted from UV radiation. There have been a number of cosmetic products added with chlorogenic acid, such as the anti-urease cosmetic, sun/UV protection ceam, hair shampoo used for preventing the damage brought by hair dye, etc.

Safety

Data suggest that chlorogenic acid is almost non-toxic, the LD50 of immature rats receiving oral administration is more than 1g/kg; receiving intraperitoneal injection it more than 0.25g/kg.